Then, you properly mention, for both cases of timeout, the target value differs application by application that there can be no meaningful target defined by multi6.
My point here was that humans-in-the-loop give up orders of magnitude sooner than FTP over TCP (to use one example). Your point, that "giving up" may involve different strategies for different applications, is helpful, but seems orthogonal to my point.
If by "most of the cases" you believe that end users will sit quietly while TCP recovers, over a period of minutes, you and I are not solving the same problem.
In the case of a computer using FTP as part of a cron job, I agree with you, but my experience is that this portion of Internet traffic is small and declining.