Things are different however for class 4. Here, renumbering is not a
realistic option. Even if renumbering the actual network infrastructure
were to be doable, changing the associated filters and related security
setups is too much work to undertake at regular intervals.
I would dispute this. All that changes is the /48 prefix, and the normal
case in IPv6 is to be running with several of those simultaneously on
any large site. Actually the filters and internal routing setup will
need to treat the top 48 bits as don't care bits.
So it seems to me that relatively simple operational procedures can deal with prefix changes.
Nevertheless, I assume that all large enterprises will choose to use a draft-ietf-ipv6-unique-local-addr-03.txt prefix for internal traffic and some VPN uses. For external traffic I assume they will use ISP-delegated prefxes, which is where multi6 comes in.