I'd perhaps reword that as "no global tunneled infrastructure". And even
then I'd be a bit hesistant: tunneling across short distances is not that
big a deal, but adding different administrative parties can make it more
and more difficult.
Solutions like ISATAP can provide rather good performance in a limited
case; connections outside of the "site" could be native v6.
That's a good point. I'm thinking of the global IPv6 infrastructure
and individual hosts or sites connecting to it. And I suspect that
any solution for this case that uses tunnels, automatic or manual, is
likely to face the problem of sub-optimal forward and/or reverse
paths that you mentioned originally. In other words 6to4 is neither
better nor worse, just different.