No, SHANTI will work out of the box for any application that runs through a traditional NAT or NAPT without problems *and* has been upgraded to AF_INET6 sockets.Ugh! Mixing IPv6 and NAT is something that I'd really like to avoid.
I've been trying to avoid it since 1994. My conclusion is that it is sadly impossible to avoid port translation, hence SHANTI. Read it before you condemn it... Brian